PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL FOR BIODISTRIBUTION OF RADIOLABELED PEPTIDES IN PATIENTS WITH NEUROENDOCRINE TUMOURS

Physiologically Based Pharmacokinetic (PBPK) model for biodistribution of radiolabeled peptides in patients with neuroendocrine tumours

Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treatedwith Lu-177 DOTATATE.The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintig

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Perioperative cancer cell dissemination detected with a real-time RT-PCR assay for EpCAM is not associated with worse prognosis in pancreatic ductal adenocarcinoma

Abstract Background Epithelial cell adhesion molecule (EpCAM) has been used as surrogate marker for the quantification of circulating tumour cells (CTC).Our aim was to prospectively study the value of a real-time RT-PCR assay for EpCAM detection in the peripheral blood and peritoneal cavity of patients undergoing pancreatectomy for pancreatic ducta

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Toxoplasma seropositivity and depression: a case report

Abstract Background The association between toxoplasmosis and psychiatric disorders has been reported in Rear End Cap a few anecdotal reports.Case Presentation A case of depression with toxoplasma seropositivity is presented.The patient with depression showed poor response to antidepressants, for which he Dryer Door Catch Spring was investigated an

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